CH 243 Organic Chemistry 3

Lecture Hours: 4
Credits: 4

Introduces the principles of organic chemistry for students majoring in physical or life sciences. Emphasizes structure, nomenclature, physical properties, and chemical reactivities of organic molecules, mechanisms of reactions, and discussion of their biological or industrial importance. Stresses carboxylic acids and their derivatives, amines, condensation reactions, carboxylics, lipids, amino acids, proteins, and nucleic acids.

Prerequisite: Placement into WR 115 (or higher), or completion of WR 090 (or higher); and completion of CH 242; or consent of instructor. (All prerequisite courses must be completed with a grade of C or better.)
Student Learning Outcomes:

Describe the structure, properties, nomenclature, synthesis and reactions of carboxylic acids, carboxylic acid derivatives and amines.
Explain the relationship between the structure of organic compounds and their subsequent physical and chemical properties.
Apply organic principles to the study of biological molecules: carbohydrates, lipids, amino acids, proteins and nucleic acids.
Recognize the organic chemistry basis of biologically important compounds and their reactions.
Assess the structures of biological molecules and their function in living systems.
Organize and maintain a laboratory notebook and prepare for experimentation in the microscale organic laboratory.
Translate the principles of organic chemistry into practical use in the organic laboratory.

Content Outline

Carboxylic Acids and their Derivatives
- Nomenclature
- Physic properties
  - Acids
  - Acid chlorides
  - Acid anhydrides
  - Esters and amides
- Reactions
  - Reduction
  - Decarboxylation
  - Chemical tests
  - Alpha substitution reactions
  - Carbonyl condensations
Amines
- Nomenclature
- Physical properties
- Biologically important amines
- Preparation
- Reactions
  - Nitrous acid
  - Arenediazonium salts
  - Sulfa drugs
  - Analysis
  - Eliminations
Carbohydrates
- Monosaccharides
  - Mutarotation
  - Glycoside formation
  - Oxidation-reduction
  - Osazone formation
  - Synthesis and degradation
  - Methylation
- Disaccharides
- Polysaccharides
- Nitrogen-containing sugars
Lipids
- Fatty acids and triacylglycerols
- Terpenes
- Steroids
- Prostaglandins
- Phospholipids
- Waxes
Amino Acids and Proteins
- Amino acids
  - Synthesis
  - Analysis
- Proteins - primary, secondary, tertiary and quaternary structure
Nucleic Acids and Protein Synthesis
- Nucleotides and nucleosides
- DNA and RNA
- Protein synthesis